Evaluation of the Palatal Wound Healing Effect of Wound Dressing Carrying GSK-3 Antagonist Tideglusib on Rats
January 2023
in “
Marmara University Open Access System
”
Studysummary This study found that tideglusib delivered topically in a bacterial cellulose hydrogel showed positive effects on the wound healing of rat palatal mucosa, as observed through macroscopic, histomorphometric, and immunohistochemical evaluations.
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The study aimed to evaluate the early effects of tideglusib (Td) applied topically with a bacterial cellulose-based hydrogel on palatal wound healing in rats. It involved 28 young adult male Sprague Dawley rats, with a 4 mm mucosal defect created in their palatal mucosa. The rats were divided into three groups: passive control, hydrogel only, and Td+Hydrogel. The results showed that the Td+Hydrogel group had statistically significant improvements in wound surface area, epithelial gap distance, and Axin2 antibody levels compared to the initial group, indicating that Td applied with hydrogel had positive effects on palatal mucosal wound healing in rats.
