Potential Therapeutic Targets for Androgenetic Alopecia in Obese Individuals Revealed by Gut Microbiome Analysis: A Mendelian Randomization Study

This study explores the connection between the gut microbiome and androgenetic alopecia (AGA) in obese individuals using Mendelian randomization. It identifies two significant gut bacterial pathways: sulfoglycolysis, which increases the risk of both obesity and AGA, and adenosine ribonucleotide de novo biosynthesis, which increases obesity risk but decreases AGA risk. These pathways could serve as therapeutic targets for managing obesity-associated AGA. The study involved a large sample size, with GWAS data from 207,036 individuals for AGA and 456,348 for obesity, enhancing the reliability of the results. However, limitations include a focus on the European population, which may affect generalizability.