Therapeutic potential of extracellular vesicles derived from Platycladus Orientalis leaf in treating anxiety, depression, and insomnia

    September 2025 in “ Frontiers in Pharmacology
    Peiyu Liu, Gang He, Yongping Lu, Juanjuan He, Fan Wu, Jia Meng, Shaochang Jia, Roger Fan, Hongwei Liang, Bing Liu, Min Li
    P. orientalis leaf-derived extracellular vesicles (EVs) show significant potential in treating anxiety, depression, and insomnia through mechanisms that regulate neurotransmitters and reduce inflammation. The study highlights the effectiveness of intranasal administration in bypassing the blood-brain barrier, suggesting that plant-derived EVs could be developed as new therapeutic options for psychiatric disorders.
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