TLDR Cyproterone acetate with ethinyl estradiol is effective for treating skin symptoms related to high androgen levels, like in PCOS.
The 2017 review concluded that cyproterone acetate (CPA) 2 mg combined with ethinyl estradiol (EE) 35 µg is effective in treating hyperandrogenic skin symptoms such as hirsutism, acne, seborrhea, and alopecia, especially in women with polycystic ovary syndrome (PCOS). The review, which included 43 studies from a literature search of the PubMed database, found that CPA/EE significantly improved skin symptoms, with the greatest improvements in hirsutism observed at 12 months. It also provided benefits in menstrual cycle regularity and quality of life, while being generally well tolerated with a side effect profile similar to combined oral contraceptives (COCs). The review noted that CPA/EE could potentially be enhanced by combining it with other treatments, although more research is needed. It also highlighted the need for continuous re-evaluation of the benefit/risk ratio, particularly in patients with additional cardiovascular risk factors. The review did not specify the number of participants in the clinical trials it included.View this study on tandfonline.com →
Hirsutism is a strong sign of high male hormones and metabolic problems in women with PCOS, but acne and hair loss are not.
Most women with excess male hormones have Polycystic Ovary Syndrome, and hormonal therapy can improve symptoms but may cause side effects.
Diane 35 plus finasteride is more effective for treating hirsutism.
Diane 35 plus finasteride is more effective in reducing hair growth and androgen levels, but may decrease libido.
Cyproterone acetate-estrogen most effective for hirsutism, but consider side effects and patient needs.
PCOS is a hormonal issue in women that is usually treated with birth control pills, metformin, and lifestyle changes, with early treatment helping to reduce complications and improve life quality.
Cyproterone acetate with ethinyl estradiol is effective for treating skin symptoms related to high androgen levels, like in PCOS.