The Protective Role of FTY720 in Promoting Survival of Allograft Fat in Mice

July 2022 in “ The Kaohsiung Journal of Medical Sciences ”

Yi Yi, Weijie Hu, Chongru Zhao, Mingchen Xiong, Qi Zhang, Yiping Wu, Hong Zeng, Ning Zeng

Fingolimod FTY720 allogeneic fat transplantation regulatory T cells macrophage infiltration anti-inflammatory cytokines IL-4 IL-10 pro-inflammatory cytokines TNF-α IL-6 CD31 positive cells angiogenesis

TLDR FTY720 helps transplanted fat survive better by reducing immune rejection and improving blood vessel growth.

The study investigated the protective effect of Fingolimod (FTY720) on allogeneic fat transplantation in C57BL/6J mice. Mice were divided into two groups, receiving either saline or FTY720 treatment. Results showed that FTY720 significantly improved allograft retention, structural integrity, and neovascularization. It increased regulatory T cell infiltration, reduced macrophage infiltration, and enhanced anti-inflammatory cytokines IL-4 and IL-10 while reducing pro-inflammatory cytokines TNF-α and IL-6. FTY720 also upregulated CD31 positive cells, indicating improved angiogenesis. The study concluded that FTY720 could enhance graft survival by suppressing immune rejection and promoting angiogenesis, suggesting its potential in drug-assisted strategies for prolonging allograft fat survival.

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