The Mineralocorticoid Receptor Plays a Transient Role in Mouse Skin Development

    August 2015 in “ Experimental Dermatology ”
    Julia Boix, Elena Carceller, Lisa M. Sevilla, Víctor Marcos‐Garcés, Paloma Pérez
    TLDR The mineralocorticoid receptor temporarily affects mouse skin development, but the glucocorticoid receptor has a more lasting impact.
    The study investigated the role of the mineralocorticoid receptor (MR) in mouse skin development, revealing that MR had a transient role in regulating epidermal differentiation during late embryonic stages. MR expression peaked at embryonic day 16.5, coinciding with low levels of the enzyme HSD11B2, suggesting a role for glucocorticoid-MR complexes in epidermal maturation. MR−/− mice exhibited increased epidermal thickness and altered keratin expression, but these changes resolved postnatally, indicating functional compensation by the glucocorticoid receptor (GR). The study concluded that while MR played a temporary role in skin development, GR had a more significant and sustained impact.
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