TLDR Keratoacanthoma changes as it grows, showing different hair follicle characteristics at each stage.
The study investigated the expression of follicular markers in keratoacanthoma (KA) across different stages, analyzing 67 tumors. It found that CK15 (clone C8/144B), CK19, and CD34 were not expressed at any stage, while CK1, CK10, CK16, CK17, CK15 (clone LHK15), and calretinin showed stage-dependent expression changes. The results indicated that KA is a follicular neoplasm with infundibular/isthmic differentiation, with early-stage tumors showing infundibular differentiation and well-developed tumors exhibiting isthmic differentiation. In the regressed stage, KAs lost follicular differentiation features and displayed epidermal characteristics. The absence of CK15 (clone C8/144B) expression did not entirely dismiss a connection between KA regression and the hair follicle cycle.
45 citations
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February 2013 in “The Journal of Dermatology” Keratoacanthoma and some squamous cell carcinomas are linked to hair follicles, while others are not.
33 citations
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April 2012 in “British Journal of Dermatology” Damaged hair follicle stem cells can cause permanent hair loss, but understanding their role could lead to new treatments.
120 citations
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August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” Cytokeratin 19 and cytokeratin 15 are key markers for monitoring the quality and self-renewing potential of engineered skin.
54 citations
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September 1999 in “PubMed” K15 staining helps distinguish basal cell carcinoma from trichoepithelioma.
198 citations
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March 1999 in “Journal of Investigative Dermatology” 133 citations
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March 1999 in “Journal of Cutaneous Pathology” Trichoepitheliomas and some basal cell carcinomas likely come from hair follicle stem cells.
50 citations
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July 2008 in “British Journal of Dermatology” 138 citations
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March 2007 in “Experimental cell research” Only a few hair-specific keratins are linked to inherited hair disorders.
276 citations
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January 2005 in “International review of cytology” The document reviewed the genomic organization and expression characteristics of human hair keratin genes, highlighting their role in hair follicle biology and hereditary disorders. It noted that research on human hair keratins lagged behind studies in other species. The review discussed the complex regulatory mechanisms of hair keratin expression and the differentiation of hair follicle compartments. It also addressed keratin-related pathologies, such as epidermolysis bullosa simplex and pachyonychia congenita, which affect the outer root sheath and nail beds, respectively. The study emphasized the need for further research to understand the molecular mechanisms governing hair follicle differentiation and keratin expression.
199 citations
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January 2004 in “The International Journal of Developmental Biology” Hair follicle growth and development are controlled by specific genes and molecular signals.
29 citations
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April 2003 in “Experimental dermatology” Human hair follicles grown in vitro maintain normal keratin patterns and structure.
175 citations
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January 1995 in “Birkhäuser Basel eBooks” 2 citations
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March 1994 in “Oncology Reports” Keratoacanthomas and squamous cell carcinomas have similar keratin patterns, making them hard to tell apart.
