The 5α-reductase inhibitor Dutasteride but not Finasteride protects dopamine neurons in the MPTP mouse model of Parkinson’s disease

    October 2015 in “Neuropharmacology
    Nadhir Litim, Mélanie Bourque, Sara Al Sweidi, Marc Morissette, Thérèse Di Paolo
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    TLDR Dutasteride protects dopamine neurons in Parkinson's mice, but Finasteride doesn't.
    The study found that Dutasteride, a 5α-reductase inhibitor, protected dopamine neurons in a mouse model of Parkinson's disease, while Finasteride had no effect. Dutasteride prevented the loss of dopamine uptake and storage, and also prevented the decrease in plasma testosterone levels induced by MPTP. The study suggests that Dutasteride may have potential as a treatment for Parkinson's disease.
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