Hypertrophic Scar Formation on Application of Terpenoid Fraction of Tuberous Root of Mirabilis Jalapa L. on Excision Wound Model in Wistar Albino Rats

The study evaluated the effects of hydromethanolic extract of M. jalapa and its terpenoid and flavonoid fractions on wound healing in Wistar Albino rats. The flavonoid-treated group showed a significant decrease in antioxidant enzyme levels, while the terpenoid fraction significantly increased growth factor expression. However, the terpenoid fraction delayed regeneration and remodeling stages, leading to a thicker ulcus layer and lack of hair follicle-like blood capillaries, potentially resulting in hypertrophic scar formation. The study concluded that the terpenoid fraction might prolong the proliferation phase, increasing the risk of hypertrophic wounds.