Tamoxifen-Associated Hirsutism: An Unusual Side Effect in a 5-Year-Old Girl with McCune-Albright Syndrome

January 2015 in “ Journal of pediatric endocrinology & metabolism/Journal of pediatric endocrinology and metabolism ”

Heves Kırmızıbekmez, Gül Yeşiltepe Mutlu, Fatma Dursun, Şükriye Pınar İşgüven

tamoxifen hirsutism McCune-Albright syndrome peripheral precocious puberty selective estrogen receptor modulator Nolvadex

TLDR A 5-year-old girl with McCune-Albright syndrome grew abnormal hair due to the drug tamoxifen.

A 5-year-old girl with McCune-Albright syndrome experienced unusual hair growth (hirsutism) approximately 2 months after starting tamoxifen treatment for peripheral precocious puberty. The pattern of terminal hair growth and the exclusion of other potential causes indicated that the hirsutism was induced by tamoxifen, a selective estrogen receptor modulator. This case highlighted an uncommon side effect of tamoxifen in pediatric patients.

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