Topical Tacrolimus Suppresses the Expression of Vascular Endothelial Growth Factor and Insulin-Like Growth Factor-1 in Late Anagen

    June 2009 in “ Clinical and Experimental Dermatology ”
    Yang Wang, Yang Wang, Lin Wu, Ping Tu
    Studysummary In this study, topical tacrolimus 0.1% ointment applied to mice skin decreased Vegf and Igf-1 mRNA levels during late anagen but did not alter hair cycling or skin appearance compared to untreated skin.
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    Research cited in this study 7

    1. Androgenetic Alopecia: Medical and Surgical Treatments Dermatologic Surgery · 2003
    2. The Expression of Insulin-Like Growth Factor 1 in Follicular Dermal Papillae Correlates with Therapeutic Efficacy of Finasteride in Androgenetic Alopecia Journal of The American Academy of Dermatology · 2003
    3. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    4. Loss of Vascular Endothelial Growth Factor in Human Alopecia Hair Follicles Journal of Investigative Dermatology · 1995
    5. A Murine Model for Inducing and Manipulating Hair Follicle Regression: Effects of Dexamethasone and Cyclosporin A Journal of Investigative Dermatology · 1994
    6. Stimulation of Hair Growth by Topical Application of FK506, a Potent Immunosuppressive Agent Journal of Investigative Dermatology · 1994
    7. Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993