Systemic Comorbidities in Korean Patients with Rosacea: Results from a Multi-Institutional Case-Control Study

The study investigated the association between rosacea and systemic comorbidities in Korean patients, involving 12,936 rosacea patients and an equal number of matched controls. Significant associations were found between rosacea and several conditions, including Sjögren syndrome, systemic sclerosis, rheumatoid arthritis, ankylosing spondylitis, autoimmune thyroiditis, alopecia areata, vitiligo, lung cancer, hepatobiliary cancer, alcohol abuse, diabetes mellitus, obesity, allergic rhinitis, allergic conjunctivitis, chronic rhinosinusitis, herpes infection, and human papillomavirus infection. Notably, certain comorbidities were more prevalent in specific demographics, such as higher odds of alopecia areata and alcohol abuse in men, and Sjögren syndrome, systemic sclerosis, and others in women. Age also influenced the prevalence of certain conditions. The study concluded that Korean patients with rosacea were more likely to experience systemic comorbidities, highlighting the need for clinicians to consider these associations in patient care.