The Effects of Synthetic 19-Norprogestins on Osteoblastic Cell Function Are Mediated by Their Non-Phenolic Reduced Metabolites

    May 2007 in “ Journal of Endocrinology ”
    Juana Enríquez, Ana E. Lemus, Jesús Chimal‐Monroy … Gregorio Pérez‐Palacios
    Studysummary This study found that A-ring reduced derivatives of norethisterone and levonorgestrel exhibit estrogen-like potency in rat osteoblasts, suggesting a mechanism for 19-norprogestins' bone restoration effects in postmenopausal women.
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    Research cited in this study 2

    1. Reduced Metabolites Mediate Neuroprotective Effects of Progesterone in the Adult Rat Hippocampus. The Synthetic Progestin Medroxyprogesterone Acetate (Provera) Is Not Neuroprotective Journal of Neurobiology · 2006
    2. Human Osteoblast-Like Cells Express Predominantly Steroid 5α-Reductase Type 1 The Journal of Clinical Endocrinology & Metabolism · 2002