The Effect of Sublingual Minoxidil on Androgenetic Alopecia in Transgender Individuals Receiving Testosterone for Gender-Affirmation: A 24-Week Single-Centre Double-Blinded, Randomized, Placebo-Controlled Clinical Trial

September 2025 in “ Journal of the American Academy of Dermatology ”

Gia Toan Tang, Shalem Leemaqz, Bevin Bhoyrul, Samantha Eisman, Rodney Sinclair, Ada S. Cheung

sublingual minoxidil androgenetic alopecia testosterone therapy hair growth placebo-controlled transgender individuals AGA Rogaine

TLDR Sublingual minoxidil significantly improves hair growth in transgender individuals on testosterone therapy.

This study investigated the effect of sublingual minoxidil on androgenetic alopecia (AGA) in transgender individuals undergoing testosterone therapy for gender affirmation. Conducted over 24 weeks, the trial was single-centre, double-blinded, randomized, and placebo-controlled. The results demonstrated that sublingual minoxidil significantly improved hair growth compared to the placebo group, suggesting its potential as an effective treatment for AGA in this population. The study's design and control measures strengthen the validity of these findings, providing a promising option for managing hair loss in transgender individuals on testosterone therapy.

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The Effect of Sublingual Minoxidil on Androgenetic Alopecia in Transgender Individuals Receiving Testosterone for Gender-Affirmation: A 24-Week Single-Centre Double-Blinded, Randomized, Placebo-Controlled Clinical Trial

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