Stem Cells in Plastic Surgery and Aesthetic Medicine

January 2023 in “ Postępy Dermatologii i Alergologii ”

Julia Katarzyna Czop, Magdalena Jałowska

adipose tissue-derived stem cells ADSCs hair regrowth skin rejuvenation fat stem cells

Studysummary This review discusses the clinical applications of adipose tissue-derived stem cells in dermatology and plastic surgery, highlighting their potential benefits but also noting existing limitations and concerns. Our plain-language summary of this paper — not a Tressless recommendation.

Stem cells, particularly adipose tissue-derived stem cells (ADSCs), have shown significant potential in aesthetic dermatology and plastic surgery due to their ease of harvest and beneficial properties. ADSCs have been found to accelerate wound healing, reduce scars, promote hair regrowth, and rejuvenate skin. Additionally, they enhance fat graft survival in procedures like breast augmentation. Despite the promising results and the development of various effective strategies, there are still limitations and concerns regarding the clinical use of stem cells.

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A Randomized, Double-Blind, Vehicle-Controlled Clinical Study of Hair Regeneration Using Adipose-Derived Stem Cell Constituent Extract in Androgenetic Alopecia

research A Randomized, Double-Blind, Vehicle-Controlled Clinical Study of Hair Regeneration Using Adipose-Derived Stem Cell Constituent Extract in Androgenetic Alopecia

25 citations , May 2020 in “Stem Cells Translational Medicine”

In this randomized clinical trial, the authors reported that adipose-derived stem cell constituent extract topical solution increased hair density and thickness in patients with androgenetic alopecia over 16 weeks compared to placebo.

research Harnessing the Power of Regenerative Therapy for Vitiligo and Alopecia Areata

26 citations , June 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

This review explores regenerative medicine approaches for vitiligo and alopecia areata, focusing on pathways for repopulating melanocytes and regrowing hair follicles, and summarizes potential treatments without reporting new clinical results.

Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations , May 2019 in “Cells”

This review discusses the advancements in intraoperative stem cell therapies and highlights their potential to improve hair regrowth, but it reports no new clinical results.

research Hair Regeneration Therapy: Application of Adipose-Derived Stem Cells

55 citations , May 2017 in “Current stem cell research & therapy”

In this study, Japanese patients treated with adipose-derived stem cell-conditioned medium for hair regeneration showed positive outcomes, suggesting it may be an effective new therapy for alopecia.

research Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging

132 citations , January 2017 in “International Journal of Molecular Sciences”

This review explores how adipose-derived stem cells contribute to skin homeostasis and highlights recent advances in their clinical applications in dermatology, but it reports no new clinical results.

research The Use of Adipose-Derived Stem Cells in Selected Skin Diseases (Vitiligo, Alopecia, and Nonhealing Wounds)

19 citations , January 2017 in “Stem Cells International”

This review discusses the potential of adipose-derived stem cells for treating vitiligo, hair loss, and chronic wound healing, but reports no new clinical results and suggests the need for further investigation.

research Stem Cells in Skin Regeneration, Wound Healing, and Their Clinical Applications

232 citations , October 2015 in “International journal of molecular sciences”

This review discusses the role of epidermal and other adult stem cells in skin repair, focusing on their potential therapeutic applications for non-healing wounds and other skin disorders, but reports no new research results.