Conditioned Media From Human Pluripotent Stem Cell-Derived Cardiomyocytes Inhibit The Growth And Migration Of Lung Cancer Cells

The study investigated the effects of conditioned media (CM) from human pluripotent stem cell-derived cardiomyocytes on lung cancer cells. Researchers treated lung cancer cell lines A549 and Calu6, as well as human foreskin fibroblasts (HFF), with cardiomyocyte CM (CCM) and fibroblast CM (FCM). They found that CCM significantly reduced the viability, growth, clonogenicity, and migration of lung cancer cells, while FCM had no such effects. The optimal concentration of CCM was determined to be 30 mg/mL. Additionally, CCM treatment led to increased apoptosis and altered gene expression in lung cancer cells, with lower levels of antiapoptotic and stemness genes and higher levels of proapoptotic genes. The study concluded that the secretome from stem cell-derived cardiomyocytes exhibited antitumor properties against lung cancer cells.