1 citations
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January 2025 in “Discrete and Continuous Dynamical Systems - B” This paper examines a chemotaxis model for alopecia areata (AA), focusing on the interactions between CD$ 4^{+} $ T cells, CD$ 8^{+} $ T cells, and interferon-gamma (IFN-$ \gamma $). The study establishes the uniform boundedness and global existence of solutions in one and two dimensions under certain conditions, such as weak signal-dependent sensitivities and high density-dependent death rates. It also explores the globally asymptotic stability and convergence rates of the model's positive equilibrium. The findings suggest that sparse hairless patches can develop and lead to stable AA when specific conditions regarding proliferation rates, death rates, and chemotactic sensitivities are met.
57 citations
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August 2023 in “American Journal of Clinical Dermatology” JAK inhibitors and platelet-rich plasma show promise for treating alopecia areata.
1 citations
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June 2023 in “Genes” Hair loss from Alopecia Areata is caused by both genes and environment, with several treatments available but challenges in cost and relapse remain.
148 citations
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December 2018 in “Journal of autoimmunity” Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.
6 citations
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June 2015 in “Journal of theoretical biology” The model showed that immune system guardians and the cytokine interferon-γ are key in alopecia areata progression.
421 citations
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April 2012 in “The New England Journal of Medicine” Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.