Possible Spironolactone Induced Intracranial Hypertension in a Patient with Androgenetic Alopecia: A Case Report

January 2018 in “ The Open Dermatology Journal ”

Hamad Fahad Albraidi, Omar Alzuman, Abdulmajeed Alajlan

spironolactone androgenetic alopecia intracranial hypertension androgen levels idiopathic papilledema

TLDR Spironolactone may cause increased brain pressure in some patients.

A case report described a patient with androgenetic alopecia who experienced a significant increase in intracranial pressure after being treated with spironolactone, a drug commonly used in dermatology for conditions with high androgen levels. The patient had a history of inactive idiopathic papilledema, which was reactivated by the medication. The symptoms resolved quickly after discontinuing spironolactone. This case highlighted the importance for physicians to be aware of rare adverse events associated with spironolactone that could lead to serious consequences.

View this study on opendermatologyjournal.com →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research A Case Series of 20 Women with Hidradenitis Suppurativa Treated with Spironolactone

54 citations, June 2015 in “Australasian Journal of Dermatology”

Spironolactone is an effective and well-tolerated first-line treatment for hidradenitis suppurativa in women.

research Prevalence and Treatment of Alopecia Areata in Taif Area, KSA

5 citations, January 2015 in “Saudi journal for health sciences”

Alopecia areata in Taif is common, mainly immune-related, and best treated with topical corticosteroids and vitamins.

research Follicular Delivery of Spironolactone via Nanostructured Lipid Carriers for Management of Alopecia

89 citations, November 2014 in “International Journal of Nanomedicine”

Using nanostructured lipid carriers to deliver spironolactone could improve treatment for hair loss.

Prevalence of Androgenic Alopecia in Patients with Polycystic Ovary Syndrome and Characterization of Associated Clinical and Biochemical Features

research Prevalence of Androgenic Alopecia in Patients with Polycystic Ovary Syndrome and Characterization of Associated Clinical and Biochemical Features

48 citations, February 2014 in “Fertility and Sterility”

Women with PCOS often have hair loss, which is linked to acne or excess body hair but not to worse hormone or metabolic issues.

research Female Pattern Hair Loss: A Review Article

57 citations, October 2013 in “international journal of endocrinology and metabolism”

Female pattern hair loss is common, linked to polycystic ovarian syndrome, and treated with topical Minoxidil.

research Successful Treatment of Female-Pattern Hair Loss with Spironolactone in a 9-Year-Old Girl

26 citations, April 2009 in “Australasian Journal of Dermatology”

Spironolactone successfully treated hair loss in a 9-year-old girl.

Related Research

4 / 4 results

The Use of Ultrasound-Targeted Microbubble Destruction Technology for Drug Delivery and Gene Transfection in the Treatment of Atherosclerosis

research The Use of Ultrasound-Targeted Microbubble Destruction Technology for Drug Delivery and Gene Transfection in the Treatment of Atherosclerosis

1 citations, November 2020 in “Journal of The American Academy of Dermatology”

GSK-36 downregulation with UTMD improves plaque stability in atherosclerosis treatment.

Spironolactone in Dermatology: Uses in Acne, Hidradenitis Suppurativa, Female Pattern Hair Loss, and Hirsutism

Possible Spironolactone Induced Intracranial Hypertension in a Patient with Androgenetic Alopecia: A Case Report

Research cited in this study

research A Case Series of 20 Women with Hidradenitis Suppurativa Treated with Spironolactone

research Prevalence and Treatment of Alopecia Areata in Taif Area, KSA

research Follicular Delivery of Spironolactone via Nanostructured Lipid Carriers for Management of Alopecia

research Prevalence of Androgenic Alopecia in Patients with Polycystic Ovary Syndrome and Characterization of Associated Clinical and Biochemical Features

research Female Pattern Hair Loss: A Review Article

research Successful Treatment of Female-Pattern Hair Loss with Spironolactone in a 9-Year-Old Girl

Related Community Posts Join

community 25F and have been losing my hair for 10 years. Been to doctors, no issues with thyroid or hormones. No history of hair loss in my family. Wtf do I do?

community Homemade topical spironolactone

community Androgenetic alopecia - I want your honest opinion

community 26 yo female with androgenetic alopecia - worried about spiro side effects and effectiveness

community WOMEN on Spironolactone - experiences?

community Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs

Related Research

research The Use of Ultrasound-Targeted Microbubble Destruction Technology for Drug Delivery and Gene Transfection in the Treatment of Atherosclerosis

research Spironolactone in Dermatology: Uses in Acne, Hidradenitis Suppurativa, Female Pattern Hair Loss, and Hirsutism

research Spironolactone for Treatment of Female Pattern Hair Loss

research Successful Treatment of Female-Pattern Hair Loss with Spironolactone in a 9-Year-Old Girl