Histological Study of Skin Aging Model Treated with Topical Mesenchymal Stem Cell-Conditioned Medium

In this study, subcutaneous injection of mesenchymal stem cell-conditioned medium promoted regeneration of mice skin aged by D-galactose, improving skin thickness, vascularization, and collagen density.

This study found that conditioned media from epidermal progenitor cells improved skin aging signs in a clinical trial and protected fibroblasts from oxidative stress in vitro.

This study found that mesenchymal stem cells mainly promote skin regeneration and delay aging through paracrine activity, releasing growth factors and cytokines that protect against oxidative stress and stimulate healing.

This study found that factors released by mesenchymal stromal cells can enhance the proliferation and migration of keratinocytes in vitro, which may contribute to improved understanding of their role in wound healing and potential applications in dermal regeneration therapies.

This review discusses mesenchymal stromal cell-conditioned medium for various skin conditions and found improvements in wound healing, hair restoration, and more, but emphasizes the need for further research to validate these findings.