Signaling Pathways Involved in Hair Follicle Cycling and Morphogenesis

The document discussed the physiological processes of hair follicles, which included embryonic hair follicle morphogenesis and the mature hair follicle cycle. During embryonic development, the position and morphological characteristics of hair follicles were determined by ectodermal cells. Once established, hair follicles entered a cyclical process influenced by external stimuli, consisting of growth, regression, and resting phases. The maintenance of hair follicle morphogenesis and cycling was regulated by a series of complex signaling pathways, including the Wnt, TGF-β/BMP, Hedgehog, FGF, Notch, and EGF pathways.