Signaling Pathways Involved in Hair Follicle Cycling and Morphogenesis

May 2012 in “ International Journal of Dermatology and Venereology ”

Qinghai Zeng, Yuanqiang Wu, Yangmei Zhou, Ling Tang

hair follicle morphogenesis anagen catagen telogen Wnt signaling pathway transforming growth factor-β bone morphogenetic protein Hedgehog signaling pathway fibroblast growth factor Notch signaling pathway epidermal growth factor

TLDR Hair growth and development are controlled by complex signaling pathways.

The document discussed the physiological process of hair follicles, which included two main phases: embryo follicle morphogenesis and mature hair follicle cycling. Hair follicles originated from ectoderm cells, with their location and morphology determined during embryonic development. Once formed, hair follicles entered a cycle influenced by external stimuli, consisting of anagen, catagen, and telogen phases. The morphogenesis and cycling of follicles were regulated by complex signaling pathways, such as Wnt, transforming growth factor-β/bone morphogenetic protein, Hedgehog, fibroblast growth factor, Notch, and epidermal growth factor.

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