Serum Levels of VWF, t-PA, TNF-α, and ICAM-1 in Patients Receiving Hemocoagulase Combined with Platelet-Rich Plasma During Total Hip Replacement

The study involved 80 osteoarthritis patients undergoing total hip replacement (THR) and examined the effects of using hemocoagulase combined with platelet-rich plasma (PRP). The patients were split into two groups: one treated with PRP and hemocoagulase, and the other with saline and thrombin. The group treated with PRP and hemocoagulase showed higher hemoglobin and hematocrit values, lower postoperative drainage volume and perioperative blood loss, and improved joint range of motion post-surgery. The study concluded that using hemocoagulase with PRP in THR can reduce blood loss, speed up wound healing, and improve coagulation and immune function. However, the PRP technique may impact the patient's hemodynamics, necessitating enhanced perioperative hemodynamic monitoring.