Correlation Between Increased Total Serum IgE Levels and Clinical Features in Alopecia Areata Patients

    June 2025 in “ Frontiers in Immunology ”
    Yijie Sun, Shuang Xu, Yujing Zhang … Cheng Zhou
    Studysummary This study found that total serum IgE levels were elevated in patients with alopecia areata compared to controls, suggesting a possible involvement of IgE and Th2 cytokines in its pathogenesis.
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    Research cited in this study 11

    1. Dupilumab and Alopecia Areata: A Possible Combined or Disturbance Therapy? A Review of the Literature Dermatology Practical & Conceptual · 2024
    2. British Association of Dermatologists Living Guideline for Managing People with Alopecia Areata 2024 British Journal of Dermatology · 2024
    3. Predictors And Management Of Inadequate Response To JAK Inhibitors In Alopecia Areata American Journal of Clinical Dermatology · 2024
    4. Dupilumab Induces Hair Regrowth in Pediatric Alopecia Areata: A Real-World, Single-Center Observational Study Archives of Dermatological Research · 2024
    5. Dupilumab Therapy for Alopecia Areata: A Case Series and Review of the Literature Journal of Dermatological Treatment · 2024
    6. Biomarkers in Alopecia Areata: A Systematic Review and Meta-Analysis Autoimmunity reviews · 2023
    7. Scalp Biomarkers During Dupilumab Treatment Support Th2 Pathway Pathogenicity in Alopecia Areata Allergy · 2022
    8. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    9. Alopecia Areata Patients Show Deficiency of FOXP3+CD39+ T Regulatory Cells and Clonotypic Restriction of Treg TCRβ-Chain, Highlighting the Immunopathological Aspect of the Disease PloS one · 2019
    10. Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients Journal of The American Academy of Dermatology · 2016
    11. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014

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