Assessment of Serum Levels of Antigliadin Antibodies (IgG and IgA) in Patients with Alopecia Areata and Their Relation to Severity of the Disease

    January 2022 in “ Al-Azhar Medical Journal ”
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    TLDR Higher antigliadin antibody levels are linked to alopecia areata severity.
    This study evaluated serum levels of antigliadin antibodies (IgA and IgG) in 30 patients with alopecia areata (AA) compared to 30 healthy controls. Results showed that antigliadin IgA was positive in 26.7% of AA patients, while IgG was positive in all AA patients and 6.7% of controls. There was a significant difference in IgA and IgG levels between patients and controls, with higher values in patients. The study found 100% sensitivity and specificity for both IgA and IgG in diagnosing AA, suggesting a strong association between antigliadin antibodies and AA severity. The study recommends serological screening for celiac disease in AA patients.
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