Serum Anti-Müllerian Hormone as a Predictor of Polycystic Ovarian Syndrome Among Women of Reproductive Age

    February 2022 in “ Research Square (Research Square) ”
    Muhammad Salman Butt, Javeria Saleem, Sobia Aiman, Rubeena Zakar, Iftikhar Sadique, Florian Fischer
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    TLDR High levels of Anti-Müllerian Hormone (AMH) in the blood can strongly predict Polycystic Ovarian Syndrome (PCOS) and related issues in women of reproductive age.
    The study analyzed the serum Anti-Müllerian Hormone (AMH) level as a predictor of Polycystic Ovarian Syndrome (PCOS) in 51 women of reproductive age recently diagnosed with PCOS. The results showed a high serum AMH level (7.23 ± 4.67 ng/ml) with normal sex hormone levels. Women with irregular or absent periods had significantly different luteinizing hormone and AMH levels compared to women with normal menstrual cycles. PCOS women with high AMH levels (≥3.9 ng/ml) showed a significant difference in ovarian morphology compared to the normal AMH group. The study concluded that serum AMH level can be used as a strong predictor for reproductive disturbances such as menstrual cycle disturbance, polycystic ovarian morphology, and clinical signs of hyperandrogenism. An elevated serum AMH level could reflect the certainty of PCOS diagnosis among women of reproductive age with a greater number of PCOS features.
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