Exploration of the Role of Anti-Mullerian Hormone and LH/FSH Ratio in Diagnosis of Polycystic Ovary Syndrome

    January 2019 in “ Clinical Endocrinology ”
    Minh Tam Le, Viet Nguyen Sa Le, Dinh Duong Le, Vu Quoc Huy Nguyen, Chen Chen, Ngoc Thanh Cao
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    TLDR The study concluded that both anti-Mullerian hormone and LH/FSH ratio are higher in women with PCOS and combining these markers with BMI could improve diagnosis accuracy.
    The study from 2019 assessed the diagnostic potential of anti-Mullerian hormone (AMH) and the LH/FSH ratio in 863 infertile Vietnamese women, aged 18-45, for polycystic ovary syndrome (PCOS). It included 441 women diagnosed with PCOS and 422 without the condition. The findings indicated that both AMH and LH/FSH ratio were significantly higher in women with PCOS. The optimal cut-off value for AMH was 32.79 pmol/L, with a sensitivity of 78.50% and specificity of 75.83%, while the LH/FSH ratio had a cut-off of 1.33, with a sensitivity of 61.68% and specificity of 86.67%. The area under the curve (AUC) for AMH was 0.852 and for LH/FSH ratio was 0.867, but the difference between them was not statistically significant (p=0.340), suggesting that neither marker is superior to the other in diagnosing PCOS. The study concluded that combining these biomarkers with other factors like BMI might enhance diagnostic accuracy.
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