Serial Sections of Atrophic Acne Scars Help in the Interpretation of Microscopic Findings and the Selection of Good Therapeutic Modalities

    November 2011 in “ Journal of the European Academy of Dermatology and Venereology ”
    W.J. Lee, Hyun-A Jung, Hyeon-Ji Lim, Yong Hyun Jang, S.‐J. Lee, D.W. Kim
    TLDR Effective acne scar treatment should use combination therapy based on specific skin changes.
    This study examined the microscopic characteristics of 31 atrophic acne scars from 5 patients to inform therapeutic approaches. Key findings included keratin plugging in hair follicle orifices (32%), multi-channelled tracts (29%), decreased dermal thickness, loss of pilosebaceous units, inflammatory cell infiltrates (77%), and insufficient dense collagen fiber deposition (29%). The study concluded that effective treatment should consider these histopathological findings and employ combination therapy.
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