93 citations
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March 2014 in “Cochrane Database of Systematic Reviews” This review concludes that although observational studies suggest a potential inverse association between selenium exposure and cancer risk, randomized trials show no convincing evidence that selenium supplements prevent cancer in humans and may indicate harmful effects.
61 citations
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May 2010 in “Integrative Cancer Therapies” This review discusses the potential benefits and risks of selenium in cancer prevention and treatment, emphasizing that while selenium may offer advantages for tumor patients, further research is needed due to mixed findings regarding diabetes risk.
January 1996 in “Human Ecology Forum” This study by Gerald Combs suggests that selenium may help prevent cancer, but both deficiency and excess can lead to serious health problems.
127 citations
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March 2004 in “Gynecologic oncology” This study concluded that selenium supplementation for ovarian cancer patients during chemotherapy may have several beneficial effects, such as increased antioxidant enzyme activity, reduced chemotherapy-related symptoms, and higher selenium levels in serum and hair.
November 2011 in “InTech eBooks” This review explores prostate cancer risk factors, screening, treatment, and potential roles of selenium and 5-alpha reductase inhibitors in risk reduction but presents no new clinical data.