Chemoprevention of Prostate Cancer

The document reviewed the potential of chemoprevention in prostate cancer, focusing on dietary factors, vitamins, and trace elements. Despite advancements in detection and management, prostate cancer remained a major health issue for men. Various European studies, including prospective, randomized, double-blinded, retrospective, and epidemiological studies, were discussed. Large-scale studies evaluated 5α-reductase inhibitors like finasteride and dutasteride, which inhibit testosterone conversion to dihydrotestosterone, to assess the benefits of androgen inhibition strategies. There was some evidence suggesting that vitamin E and selenium might contribute to chemoprevention. However, the review concluded that there was a lack of robust evidence supporting the effectiveness of chemopreventive agents.