The Carcinogenesis Of The Human Scalp: An Immunometabolic-Centered View

    Baruch Kaplan, Rebecca von Dannecker, Jack L. Arbiser
    Studysummary In this review, the authors discuss how hair may protect against scalp skin cancer by enabling IL-17-biased immunosurveillance, while hair loss could permit tumor development by reducing this immune protection.
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    Research cited in this study 11

    1. Deciphering the Molecular Mechanisms of Stem Cell Dynamics in Hair Follicle Regeneration 2024
    2. Aging of Hair Follicle Stem Cells and Their Niches Journal of Biochemistry and Molecular Biology · 2022
    3. A Cross-Sectional Study of Clinical, Dermoscopic, Histopathological, and Molecular Patterns of Scalp Melanoma in Patients With or Without Androgenetic Alopecia Scientific Reports · 2022
    4. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    5. Diagnosis and Management of Melanoma of the Scalp: A Review of the Literature Clinical, Cosmetic and Investigational Dermatology · 2021
    6. Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss Journal of Medicinal Chemistry · 2021
    7. Age-Related Changes in Female Scalp Dermal Sheath and Dermal Fibroblasts: How the Hair Follicle Environment Impacts Hair Aging Journal of Investigative Dermatology · 2020
    8. Exploring the Possibility of Predicting Human Head Hair Greying from DNA Using Whole-Exome and Targeted NGS Data BMC Genomics · 2020
    9. Human Hair as a Natural Sun Protection Agent: A Quantitative Study Photochemistry and Photobiology · 2015
    10. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    11. The Hair Growth Promoting Effect of 4-O-Methylhonokiol European Journal of Dermatology · 2011