First-In-Human Study to Investigate the Safety Assessment of Peri-Implant Soft Tissue Regeneration with Micronized Gingival Connective Tissue: A Pilot Case Series Study

This pilot case series study, conducted at Nagasaki University, investigated the safety and preliminary efficacy of micronized-gingival connective tissues (MGCTs) for peri-implant mucosa regeneration in dental implant therapy. Involving 4 patients, the study found that MGCTs did not cause any irreversible adverse events and showed potential efficacy for reconstructing peri-implant soft tissues. The procedure demonstrated successful regeneration of peri-implant mucosa over a 16-week period, suggesting MGCTs as a promising alternative to traditional grafting methods due to their low morbidity and ease of use. However, further studies on a larger scale were needed to confirm these findings.