Preparation of ROS-Responsive Drug-Loaded Particles and Microneedles for Diabetic Wound Healing

The study addresses the challenge of treating diabetic wounds, which are complicated by excessive reactive oxygen species (ROS). Traditional methods are often ineffective due to limited penetration through biofilms. Researchers developed microneedles made from benzene boric acid-grafted polyphosphazene, which are designed to enhance wound healing. These microneedles are loaded with green tea polyphenols (TP) that are released in response to ROS, allowing deeper skin penetration. The matrix of the microneedles is composed of sodium hyalurate (HA), which also aids in wound healing. Testing on a diabetic rat model showed that these microneedles significantly improved wound healing. The authors report no conflicts of interest, and data supporting the study's findings are available upon request.