Role of the Notch Ligand Delta1 in Embryonic and Adult Mouse Epidermis

October 2007 in “ Journal of Investigative Dermatology ”

Soline Estrach, Ralf Cordes, Katsuto Hozumi, Achim Gossler, Fiona M. Watt

Notch ligand Delta1 Dll1 interfollicular epidermis IFE keratin marker epidermal tumor keratinocytes Jagged1 hair follicle differentiation

TLDR Delta1 is crucial for controlling skin cell growth and preventing tumors in mice.

The study examined the role of the Notch ligand Delta1 (Dll1) in mouse epidermis, finding that Dll1 was crucial for regulating interfollicular epidermis (IFE) proliferation and differentiation, but not essential for maintaining adult hair follicles. Deletion of Dll1 led to increased IFE proliferation, disturbed keratin marker expression, and epidermal tumor formation in older mice, indicating a role in tumor suppression. Dll1-null keratinocytes showed increased proliferation and differentiation in vitro. The study highlighted distinct roles for Dll1 and Jagged1, with Dll1 primarily affecting IFE dynamics and Jagged1 more involved in hair follicle differentiation.

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Research cited in this study

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Localization of Members of the Notch System and the Differentiation of Vibrissa Hair Follicles: Receptors, Ligands, and Fringe Modulators

research Localization of Members of the Notch System and the Differentiation of Vibrissa Hair Follicles: Receptors, Ligands, and Fringe Modulators

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research Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages during Skin Development

318 citations , October 1998 in “The Journal of Cell Biology”

The study investigated the expression of keratin 17 (K17) during mouse skin development, revealing that K17 synthesis began in embryonic day 10.5 in a subset of epithelial cells. These cells later formed placodes, precursors to ectoderm-derived appendages like hair, glands, and teeth. The spatial distribution of K17 corresponded with lymphoid-enhancer factor (lef-1), a protein involved in epithelial–mesenchymal interactions. Ectopic expression of lef-1 in adult transgenic mice induced K17, suggesting a link between K17 expression, skin morphogenesis, and wound repair. This research highlighted the role of K17 in skin development and its potential involvement in epithelial lineage definition.

research Mouse Notch: Expression in Hair Follicles Correlates with Cell Fate Determination

150 citations , May 1993 in “The journal of cell biology/The Journal of cell biology”

Mouse Notch is important for determining cell roles in hair follicles.

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