The Role of T-Helper 17 Cells and Regulatory T Cells in Acute Diffuse and Total Alopecia: The Increased Function of Regulatory T Cells May Explain the Favorable Prognosis

    May 2025 in “ The Journal of Dermatology ”
    Ji‐Hoon Lim, Da‐Hyun Kang, Haena Moon … Bark‐Lynn Lew
    Studysummary In this study, increased Treg cell activity indicated by IL-10 and IL-15 was identified as a feature of ADTA, distinguishing it from AA and potentially explaining ADTA's more favorable prognosis.
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    Research cited in this study 6

    1. Guidelines for the Management of Patients with Alopecia Areata in Korea: Part I Topical and Device-Based Treatment Annals of Dermatology · 2023
    2. Biomarkers of Alopecia Areata Disease Activity and Response to Corticosteroid Treatment Experimental dermatology · 2015
    3. Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2015
    4. Imbalance of T-Helper 17 and Regulatory T Cells in Patients with Alopecia Areata The Journal of Dermatology · 2015
    5. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    6. Acute Diffuse And Total Alopecia: A New Subtype Of Alopecia Areata With A Favorable Prognosis Journal of The American Academy of Dermatology · 2008

    Related research 1

    1. Serum Zinc Concentration in Patients With Alopecia Areata Acta dermato-venereologica (Print) · 2023