Evaluation of the Role of CXCL12 in Cases of Alopecia Areata

April 2025 in “ ALEXMED ePosters ”

Wafaa Abdallah, Eman M Eleryan, Mona Tahoun, Israa Khaled Shaddad Zreid

CXCL12 alopecia areata immune-mediated disorder nonscarring hair loss angiogenesis endothelial progenitor cells vascular support hair follicles autoimmune mechanisms γδ T cells autoimmune attack AA immune disorder hair loss blood vessel formation blood vessel support immune system T cells

This study explores the dual role of CXCL12 in alopecia areata (AA), an immune-mediated disorder causing nonscarring hair loss. CXCL12 is involved in angiogenesis by attracting endothelial progenitor cells, and decreased levels may impair vascular support to hair follicles, contributing to hair loss. Conversely, CXCL12 is also implicated in autoimmune mechanisms, where its overexpression recruits γδ T cells to stressed hair follicles, exacerbating the autoimmune attack and leading to hair loss. The study highlights the complex role of CXCL12 in the pathogenesis of AA.

View this study on alexpos.journals.ekb.eg →

Discuss this study in the Community →