Recurrent Priapism in a Sickle Cell Disease Patient Treated with Gonadotropin-Releasing Hormone Agonists: A Case Report

A 34-year-old male with sickle cell disease experienced recurrent ischemic priapism, unresponsive to standard treatments, including oral etilefrine and bicalutamide. As a last resort before considering penile prosthesis, he was treated with goserelin, a gonadotropin-releasing hormone (GnRH) agonist, which resulted in significant clinical improvement, cessation of stuttering priapism, and recovery of erectile function. The patient opted to continue hormonal therapy, avoiding surgery. This case highlights the potential of GnRH agonists in managing recurrent priapism in sickle cell patients, though long-term safety remains uncertain and warrants further study.