Recurrent Priapism in a Sickle Cell Disease Patient Treated with Gonadotropin-Releasing Hormone Agonists: A Case Report

This case report discusses the treatment of recurrent priapism in a 34-year-old male with sickle cell disease using gonadotropin-releasing hormone (GnRH) agonists. Despite various treatments, including aspirin, hydroxyurea, finasteride, and monthly exchange transfusions, the patient experienced daily painful erections. Oral etilefrine and bicalutamide were ineffective, with the latter causing painful gynecomastia. As a last resort before considering penile prosthesis, the patient was treated with goserelin, a GnRH agonist, which led to significant clinical improvement and cessation of stuttering priapism. The patient regained satisfactory erectile function and opted to continue hormonal therapy. The report highlights the effectiveness of GnRH agonists in managing symptoms and improving quality of life, though it notes the need for further studies on long-term safety.