Re-Innovation in Clinical Trial Designs Based on Precision Therapy

    September 2025 in “ Cancer Innovation ”
    Shenglan Li, Jiachen Wang, Zhuang Kang, Xun Kang, Feng Chen, Wenbin Li
    Image of study
    TLDR Clinical trials should use innovative designs and biomarkers to improve precision therapy and patient outcomes.
    The article emphasizes the need for re-innovation in clinical trial designs to enhance precision therapy, criticizing traditional trials for their inefficiencies. It advocates for using biomarker technology and innovative designs like basket, umbrella, and platform trials to align therapies with patient characteristics in real-time. Examples such as the BFAST trial and FUTURE series demonstrate improved patient outcomes through targeted treatments. The document also highlights the use of MAMS designs for efficiency, as seen in the ROSSINI-2 trial, which reduced sample size while maintaining statistical power. Additionally, it explores the therapeutic potential of compounds like chlorogenic acid and honokiol, noting unexpected benefits such as hair growth. The integration of biomarkers and adaptive protocols is crucial for optimizing patient treatment and trial outcomes, underscoring the transformative potential of precision medicine.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 39 results

      community How true is the statement: dead follicles don't grow back?

      in Research/Science  107 upvotes 6 months ago
      Hair follicles usually go dormant rather than die, and treatments like finasteride, minoxidil, and hormone therapy can sometimes reactivate them, though results vary. Complete regrowth is rare, especially in long-term bald areas, but some individuals see significant improvement with these treatments.

      community Is Topical Fin a Reasonable Alternative?

      in Finasteride/Dutasteride  6 upvotes 4 years ago
      A user discusses mild/moderate hair loss and considers switching from oral to topical finasteride due to past endocrine issues. They seek feedback on topical finasteride's effectiveness and reputable sources, with replies suggesting Minoxidilmax products as effective alternatives.

      community Only finasteride 1.25 for 5 months

      in Progress Pictures  1046 upvotes 1 year ago
      The conversation is about a user's hair regrowth after using only finasteride for 5 months, with some users expressing congratulations and curiosity about the lack of minoxidil use and potential side effects.

      community Well boys, it was worth a shot…

      in Update  430 upvotes 3 months ago
      The user has been using oral finasteride, minoxidil, and supplements for six months with some progress in hair loss treatment. They are considering a hair transplant and have been advised to continue the current regimen for 12-18 months, possibly adding microneedling or trying dutasteride.

      community Yes your lifestyle and diet has its role in hair loss.

      in Chat  296 upvotes 1 month ago
      Diet and lifestyle changes can reduce hair shedding but won't regrow hair lost to genetic male pattern baldness. Treatments like finasteride and dutasteride are necessary for significant hair regrowth.

    Similar Research

    5 / 1000+ results