Burden of Alopecia Areata in China, 1990–2021: Global Burden of Disease Study 2021

November 2024 in “ Chinese Medical Journal ”

Xiangqian Li, Huixin Liu, Wenhui Ren, Qijiong Zhu, Peng Yin, Lijun Wang, Jianzhong Zhang, Jinlei Qi, Cheng Zhou

Studysummary This study highlights that alopecia areata remains a pressing public health issue in China, especially affecting young people and females, who bear a disproportionately high burden of this condition.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

Alopecia areata (AA) remains a significant public health issue in China, with no indication of decreasing prevalence from 1990 to 2021. The study highlights the need for targeted interventions, particularly for young individuals and females, who bear a disproportionately high burden of the condition.

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Research cited in this study

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research Evaluating the Cost Burden of Alopecia Areata Treatment: A Comprehensive Review for Dermatologists

2 citations , April 2024 in “Cutis”

This study reported that despite the limited effectiveness of many current therapies for alopecia areata, patients face substantial financial burdens managing the condition, based on an analysis of ten studies involving approximately 16,000 patients.

research European Expert Consensus Statement on the Systemic Treatment of Alopecia Areata

4 citations , January 2024 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

This consensus statement outlines a treatment algorithm for alopecia areata, detailing systemic treatment indications and options, including EMA-approved medications baricitinib and ritlecitinib for severe cases, as well as other off-label treatments and adjuvant therapies like oral minoxidil.

research Epidemiology of Alopecia Areata and Population-Wide Comorbidities in Germany: Analysis of Longitudinal Claims Data

1 citations , October 2023 in “British journal of dermatology/British journal of dermatology, Supplement”

This study found that, in Germany between 2016 and 2020, alopecia areata had an annual prevalence of 210 cases per 100,000 and an incidence of 72 cases per 100,000, with higher rates in specific regions and associated with comorbidities like atopic dermatitis and psoriasis.

research Alopecia Areata: What's New in the Epidemiology, Comorbidities, and Pathogenesis?

49 citations , October 2023 in “Journal of Dermatological Science”

research Associations Between Season, Climate, and Pediatric Alopecia Areata Flares in Providence, Rhode Island

5 citations , September 2023 in “Archives of Dermatological Research”

In this retrospective study of 123 pediatric alopecia areata patients, hair loss episodes were most frequent in winter and showed significant correlations with air pressure and hours of sunlight, especially in non-atopic individuals, suggesting a role for climate factors in seasonal hair loss patterns.

Incidence and Prevalence of Alopecia Areata in the Australian Primary Care Setting: A Retrospective Analysis of Electronic Health Record Data

research Incidence and Prevalence of Alopecia Areata in the Australian Primary Care Setting: A Retrospective Analysis of Electronic Health Record Data

July 2023 in “Australasian Journal of Dermatology”

This study described the incidence and prevalence of alopecia areata in Australia's primary healthcare population, finding the highest incidence in individuals aged 19 to 34, with males more affected than females.

research Efficacy and Safety of Ritlecitinib in Adults and Adolescents With Alopecia Areata: A Randomised, Double-Blind, Multicentre, Phase 2b–3 Trial

227 citations , April 2023 in “The Lancet”

Ritlecitinib effectively treats alopecia areata and is well-tolerated.

research Trends in Prevalence and Incidence of Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Among Adults and Children in a US Employer-Sponsored Insured Population

75 citations , March 2023 in “JAMA Dermatology”

This study reported that the prevalence of alopecia areata in the US slightly increased from 0.199% to 0.222% between 2016 and 2019, with higher rates observed in women and adults.

research The Burden of Alopecia Areata: A Scoping Review Focusing on Quality of Life, Mental Health, and Work Productivity

10 citations , January 2023 in “Journal of the European Academy of Dermatology and Venereology”

This review highlights the significant negative impact of alopecia areata on quality of life, mental health, and work, calling for individualized approaches and effective treatments to mitigate these effects.

research Prevalence, Comorbidities, and Treatment Patterns of Japanese Patients with Alopecia Areata: A Descriptive Study Using Japan Medical Data Center Claims Database

35 citations , November 2022 in “The Journal of Dermatology”

This study found that the prevalence of alopecia areata in Japan increased from 2012 to 2019, with allergic diseases as common comorbidities and a need for more effective treatments, particularly for severe and pediatric cases.

research Two Phase 3 Trials of Baricitinib for Alopecia Areata

148 citations , March 2022 in “The New England Journal of Medicine”

In two phase 3 trials, this study found that oral baricitinib significantly improved hair regrowth compared to placebo in adults with severe alopecia areata after 36 weeks, though longer trials are needed to ascertain its long-term efficacy and safety.

research Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management

290 citations , August 2021 in “Clinical Reviews in Allergy & Immunology”

JAK inhibitors show promise for treating alopecia areata, but more research is needed.

research Alopecia Areata and Toxic Metals

4 citations , January 2020 in “Skin appendage disorders”

This study highlighted that toxic metals, particularly thallium, arsenic, selenium, and mercury, are commonly associated with cases of alopecia areata.

Alopecia Areata: A Multifactorial Autoimmune Condition