Quiescent and Aging Hair Follicle Stem Cells

February 2016 in “ Science ”

B. A. Purnell

hair follicle stem cells Foxc1 transcription factor Nfatc1 BMP signaling type XVII collagen COL17A1 epidermal keratinocytes hair follicle shrinkage

TLDR Foxc1 and COL17A1 are crucial for maintaining healthy hair follicles and preventing hair loss.

Two studies explored the characteristics of hair follicle stem cells, which are crucial for hair growth and maintenance. Wang et al. discovered that the Foxc1 transcription factor is activated in hair follicle stem cells, promoting Nfatc1 and BMP signaling to maintain their quiescent state. Matsumura et al. focused on aging hair follicle stem cells and identified type XVII collagen (COL17A1) as essential for preventing hair thinning. They found that DNA damage led to the depletion of COL17A1, causing cell differentiation and the loss of epidermal keratinocytes, which resulted in hair follicle shrinkage and hair loss.

View this study on science.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Fats on your Head to Stop Hair Loss?

in Research/Science 138 upvotes 1 year ago

The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Massive hair gains! Hope! May this post be a light to you in dark phases when all other lights go out

in Progress Pictures 193 upvotes 1 year ago

A 27-year-old man saw significant hair regrowth after starting a regimen in January that included topical minoxidil with finasteride, vitamins D and B12, fish oil, zinc with magnesium, quitting smoking, and intermittent fasting. People commented on the effectiveness of minoxidil in Southern populations and asked about the details and timeline of his treatment.

community Physio-metabolic method (antiandrogen, minoxidil, leg training and cold)

in Treatments 309 upvotes 1 year ago

The method combines finasteride, minoxidil, intense leg exercises, and cold exposure to treat androgenetic alopecia. It aims to boost metabolism and reduce androgenic effects, enhancing hair growth.

community How does dutasteride regrowth work?

in Finasteride/Dutasteride 7 upvotes 1 year ago

A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

community "Hair Follicle Stem Cells are quiescent 99% of the time and permanently reside in the hair follicle"

in Research/Science 1393 upvotes 2 months ago

Hair follicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.

Similar Research

5 / 1000+ results

research Foxc1 Reinforces Quiescence in Self-Renewing Hair Follicle Stem Cells

142 citations , February 2016 in “Science”

Foxc1 helps keep hair follicle stem cells inactive, preventing hair loss.

All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

research All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

January 2018 in “Stem cell biology and regenerative medicine”

The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.

Aging in Hair Follicle Stem Cells and Niche Microenvironment