The New Regenerative and Innovative Strategies in Hair Loss

June 2021

Pietro Gentile

ALRV5XR botanical extracts vitamins minerals anagen phase neogen autologous platelet-rich plasma PRP Adult Stem Cell-based therapy A-SC-BT growth factors cell proliferation differentiation neo-angiogenesis stem cell therapy

Studysummary In a randomized, double-blinded, placebo-controlled clinical trial, this study found that the botanical-based compound ALRV5XR significantly increased hair regrowth in women with androgenetic alopecia or telogen effluvium, with no adverse events reported.

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The document discusses the rise in clinical trials evaluating new regenerative and innovative strategies for treating male and female pattern hair loss. One such strategy involves a compound called "ALRV5XR", derived from botanical extracts, vitamins, and minerals, which has shown promising results in a randomized, double-blinded, placebo-controlled clinical trial. This compound aims to prolong the anagen phase of hair follicles and induce neogen in involuted hair follicles. The document also highlights the increasing use of autologous platelet-rich plasma (PRP) and Adult Stem Cell-based therapy (A-SC-BT) in treating hair loss. PRP, which contains growth factors, promotes cell proliferation, differentiation, and neo-angiogenesis, thereby stimulating hair growth. A-SC-BT is also gaining interest for its potential in hair regrowth. However, the document notes that more systematic reviews and randomized controlled trials are needed to confirm the standardized use of these regenerative and innovative strategies in hair loss treatment.

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Research cited in this study

7 / 7 results

research Safety and Efficacy of ALRV5XR in Women with Androgenetic Alopecia or Telogen Effluvium: A Randomised, Double-Blinded, Placebo-Controlled Clinical Trial

6 citations , June 2021 in “EClinicalMedicine”

In this study, ALRV5XR significantly increased hair regrowth in women with androgenetic alopecia or telogen effluvium, with no adverse events reported.

A Randomized Blinded Retrospective Study: The Combined Use of Micro-Needling Technique, Low-Level Laser Therapy, and Autologous Non-Activated Platelet-Rich Plasma Improves Hair Re-Growth in Patients with Androgenic Alopecia

research A Randomized Blinded Retrospective Study: The Combined Use of Micro-Needling Technique, Low-Level Laser Therapy, and Autologous Non-Activated Platelet-Rich Plasma Improves Hair Re-Growth in Patients with Androgenic Alopecia

20 citations , July 2020 in “Expert Opinion on Biological Therapy”

This study found that combining micro-needling, low-level laser therapy, and autologous non-activated platelet-rich plasma increased hair density in patients with androgenic alopecia over the treatment period.

Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

research Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

65 citations , April 2020 in “International Journal of Molecular Sciences”

This review indicates that most studies reported positive effects of platelet-rich plasma injections for treating androgenic alopecia, with no major side effects, suggesting it may be a safe alternative to Minoxidil and Finasteride.

Impact of Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma and Activated Platelet-Rich Plasma in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

research Impact of Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma and Activated Platelet-Rich Plasma in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

58 citations , January 2020 in “International Journal of Molecular Sciences”

This review evaluates various kits for isolating platelet-rich plasma using established processing standards and finds they enable compliance with consensus quality criteria; ongoing research is needed to refine these procedures for improved consistency and safety.

research Autologous Micrografts from Scalp Tissue: Trichoscopic and Long-Term Clinical Evaluation in Male and Female Androgenetic Alopecia

41 citations , January 2020 in “BioMed Research International”

This study found that micrografts containing human hair follicle mesenchymal stem cells significantly increased hair count and density compared to placebo over 58 weeks in patients experiencing hair loss.

research Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia

88 citations , July 2019 in “International Journal of Molecular Sciences”

In this study of patients with Androgenic Alopecia, micro-grafts containing HD-AFSCs resulted in significantly improved hair density and follicle count over 11 months compared to a saline solution, suggesting a potential alternative therapy for hair regrowth.

research The Biology of Hair Follicles

1113 citations , August 1999 in “The New England Journal of Medicine”

This article discusses the biologic and psychosocial significance of hair, the current limitations in hair growth drugs, and anticipates future therapies based on advancing hair follicle research.