Ectoderm-Targeted Overexpression of the Glucocorticoid Receptor Induces Hypohidrotic Ectodermal Dysplasia

    March 2005 in “ Endocrinology ”
    José Luis Cascallana, Ana Bravo, Eva Donet … Paloma Pérez
    Studysummary In this study, ectoderm-targeted transgenic mice with glucocorticoid receptor overexpression exhibited multiple epithelial defects, suggesting the role of NF-kappaB and p63 dysfunction in ectodermal dysplasia syndromes.
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    Research cited in this study 2

    1. Altered Skin Development and Impaired Proliferative and Inflammatory Responses in Transgenic Mice Overexpressing the Glucocorticoid Receptor The FASEB Journal · 2001
    2. Glucocorticoid Effect on Hair Growth Initiation: A Reconsideration Skin Pharmacology and Physiology · 1993

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