A WWP2–PTEN–KLF5 Signaling Axis Regulates Odontoblast Differentiation and Dentinogenesis in Mice

    July 2022 in “ Journal of Biological Chemistry ”
    Jing Fu, Xiaobo Zhang, Huiwen Zheng … Guohua Yuan
    Studysummary This study in mice found that WWP2 facilitates odontoblast differentiation and dentin formation by targeting PTEN for degradation, thereby enhancing KLF5 activity, which may suggest its crucial role in dental development.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on jbc.org →
    Discuss this study in the Community →

    Research cited in this study 1

    1. BMP2-Mediated PTEN Enhancement Promotes Differentiation of Hair Follicle Stem Cells by Inducing Autophagy Experimental cell research · 2019