Role of Platelet and Growth Factor Concentration in Platelet Rich Plasma Therapeutic Response to Alopecia
July 2022
in “
Journal of Investigative Dermatology
”
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Studysummary This study suggests that high platelet concentrations in PRP may not be necessary for hair growth in androgenetic alopecia, and certain growth factors might negatively impact clinical outcomes.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The document presents a case series of 3 patients with androgenetic alopecia (AGA) who underwent platelet rich plasma (PRP) therapy, a treatment for hair loss. The PRP used contained platelet concentrations that were 15-55% of the baseline in the blood. The patients received 3 treatments over a 6-month period. The results showed that patient A had the best response with a 20-50% increase in hair density and a 20% increase in average hair width across 3 scalp regions. Patient B improved slightly, while patient C’s AGA remained stable. The study found no fibroblast growth factor 2 (FGF2) in all of patient A samples, whereas the platelets of patient B and C secreted FGF2 upon activation. The data suggests that high platelet numbers in PRP samples may not be necessary for hair growth and highlights key growth factors that may have a negative effect on clinical response.
