A Split Scalp Study of Single Versus Double Spin Platelet-Rich Plasma Injections in Treatment of Female Pattern Hair Loss: Clinical Effect and Relation to Vascular Endothelial Growth Factor in PRP

October 2021 in “ QJM: An International Journal of Medicine ”

Samar Abdallah M. Salem, Rania Mahmoud Elhusseiny, Haitham Mohamed Saleh

platelet-rich plasma PRP female pattern hair loss FPHL vascular endothelial growth factor VEGF double-spin PRP single-spin PRP calcium activation

TLDR Double-spin PRP is more effective for treating female hair loss than single-spin PRP.

This study compared the efficacy of single-spin versus double-spin platelet-rich plasma (PRP) injections in treating female pattern hair loss (FPHL) in 15 female patients. Each patient received double-spin PRP on one half of the scalp and single-spin PRP on the other half, with three treatment sessions spaced three weeks apart. Results showed significant improvement in hair density on the side treated with double-spin PRP, as evidenced by patient photographs and folliscopic assessments. However, the concentration of vascular endothelial growth factor (VEGF) did not significantly differ between the two PRP preparations, nor did it increase with calcium activation. The study concludes that double-spin PRP may be more effective for FPHL treatment than single-spin PRP, but further research with larger sample sizes is needed to refine PRP preparation methods.

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