Psoriasis Patients Demonstrate HLA-Cw*06:02 Allele Dosage-Dependent T Cell Proliferation When Treated With Hair Follicle-Derived Keratin 17 Protein

April 2018 in “ Scientific Reports ”

Milyausha M. Yunusbaeva, Р. З. Валиев, Fanil Bilalov, З И Султанова, Leyla Sharipova, Bayazit Yunusbayev

keratin 17 K17 HLA-Cw*06:02 T cell proliferation autoantigen psoriasis

TLDR Psoriasis patients' immune response to a hair protein depends on their specific gene type.

The study investigated the role of the keratin 17 (K17) protein, derived from hair follicles, as a potential autoantigen in psoriasis. Researchers synthesized K17 protein and tested its effect on T cell proliferation in patients with different genotypes at the HLA-Cw*06:02 locus. The results showed a significant increase in T cell proliferation in psoriasis patients compared to healthy controls, with the response strongly correlated to the dosage of the HLA-Cw*06:02 allele. This suggested that K17 might act as an autoantigen in psoriasis, and the patient's genotype at this locus was a strong predictor of the immune response.

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