Platelet-Rich Plasma Therapy in the Treatment of Recalcitrant Melasma

This review discusses the potential use of platelet-rich plasma for treating melasma, suggesting its effectiveness but noting the need for more extensive studies to confirm these findings.

This review found that platelet-rich plasma shows potential in improving melasma, though its overall benefit varies across different treatment methods and may not enhance results when combined with certain other treatments.

In this study, PRP was found to show promise in treating melasma, offering consistent positive outcomes and satisfaction rates among patients, especially when combined with treatments like hydroquinone and tranexamic acid, though further research is needed to confirm long-term efficacy and safety.

Intradermal PRP significantly improved melasma in dark skin, with lasting results and no relapse after 3 months.

In this study, I-PRF, a blood-derived biomaterial without anticoagulants, was found to inhibit melanin production and reduce oxidative stress damage in a rat model of melasma, suggesting it as a safe and cost-effective treatment option.