Pre‐polycystic ovary syndrome and polymenorrhoea as new facets of polycystic ovary syndrome (PCOS): Evidences from a single centre data set

September 2023 in “ Clinical Endocrinology ”

Mohd Ashraf Ganie, Aafia Rashid, Mohammad Salem Baba, Mohammad Afzal Zargar, Imtiyaz Ahmad Wani, Sobia Nisar, Ishfaq Ahmad Wani, Syed Douhath, Mukesh Sriwastawa, Mohd Ishaq Geer, Mir Mohd Asrar, Rintu Kutum, Saqib Hassan, Shahid Anis Khan, Wajid Rafi, Dil Afroz Bhat, Wasia Showkat, Tajali Sahar, Naseer A. Choh, Rabia Khurshid, Syed Mudassar, Zafar A. Shah, Iram Shabir, Sanjeed Ahmad Sofi, Nandita Gupta, Imran Hafeez, Vishnubatla Sreenivas

TLDR Polymenorrhoea should be included in PCOS diagnostic criteria due to similar metabolic issues.

This study investigates the metabolic implications of polymenorrhoea and partial PCOS phenotypes in a cohort of 6,463 women with PCOS-like characteristics and 3,142 healthy controls. It found that 5,174 women met the Rotterdam criteria for PCOS, while 737 were classified as Pre-PCOS. Common features included oligomenorrhoea, hirsutism, obesity, and metabolic syndrome. Women with PCOS, hyperandrogenism (HA), and oligo-amenorrhoea (OA) had higher BMI, plasma glucose, and lipid levels compared to those with polycystic ovarian morphology (PCOM) and healthy controls. The polymenorrhoea subgroup showed similar metabolic dysfunctions to the oligomenorrhoea group, suggesting the need to include polymenorrhoea in PCOS diagnostic criteria.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

The Prevalence of Polycystic Ovary Syndrome, Its Phenotypes and Cardio-Metabolic Features in a Community Sample of Iranian Population: Tehran Lipid and Glucose Study

research The Prevalence of Polycystic Ovary Syndrome, Its Phenotypes and Cardio-Metabolic Features in a Community Sample of Iranian Population: Tehran Lipid and Glucose Study

9 citations , March 2022 in “Frontiers in Endocrinology”

About 19.4% of Iranian women in the study have Polycystic Ovary Syndrome, with the most common type involving irregular periods and high male hormone levels, but their heart and metabolic health is similar to women without the condition.

research Clinical and Biochemical Characteristics in PCOS Women With Menstrual Abnormalities

3 citations , December 2016 in “PubMed”

Menstrual abnormalities in PCOS women may not greatly affect their metabolic and hormonal profile.

Oral Glucose Tolerance Test Significantly Impacts the Prevalence of Abnormal Glucose Tolerance Among Indian Women With Polycystic Ovary Syndrome: Lessons From a Large Database of Two Tertiary Care Centers on the Indian Subcontinent

research Oral Glucose Tolerance Test Significantly Impacts the Prevalence of Abnormal Glucose Tolerance Among Indian Women With Polycystic Ovary Syndrome: Lessons From a Large Database of Two Tertiary Care Centers on the Indian Subcontinent

22 citations , September 2015 in “Fertility and Sterility”

The oral glucose tolerance test is effective in detecting abnormal glucose tolerance in Indian women with PCOS.

research Clinical Characteristics of Polycystic Ovary Syndrome: Investigating Differences in White and South Asian Women

29 citations , March 2015 in “Clinical Endocrinology”

South Asian women with PCOS present with different symptoms compared to White women, influenced by ethnicity, obesity, and age.

Improved Efficacy of Low-Dose Spironolactone and Metformin Combination Than Either Drug Alone in the Management of Women With Polycystic Ovary Syndrome: A Six-Month, Open-Label Randomized Study

research Improved Efficacy of Low-Dose Spironolactone and Metformin Combination Than Either Drug Alone in the Management of Women With Polycystic Ovary Syndrome: A Six-Month, Open-Label Randomized Study

75 citations , July 2013 in “The Journal of Clinical Endocrinology and Metabolism”

Taking low-dose spironolactone and metformin together works better for PCOS symptoms than either drug alone.

research The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report

1540 citations , October 2008 in “Fertility and Sterility”

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

Comparison of Clinical and Laboratory Characteristics of Cases with Polycystic Ovarian Syndrome Based on Rotterdam’s Criteria and Women with Only Oligo/Anovulation or Hirsutism

research Comparison of Clinical and Laboratory Characteristics of Cases with Polycystic Ovarian Syndrome Based on Rotterdam’s Criteria and Women with Only Oligo/Anovulation or Hirsutism

38 citations , May 2006 in “Archives of Gynecology and Obstetrics”

Women with only irregular periods or excess hair have a better hormone profile than those with full PCOS, but both groups are similar, indicating a need for better PCOS diagnosis methods.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

4809 citations , January 2004 in “Fertility and Sterility”

The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.

research Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex

666 citations , September 1977 in “British Journal of Dermatology”

Common baldness, also known as Androgenetic Alopecia, is caused by a combination of genetic factors and hormones called androgens.

Related Research

4 / 4 results

research Correlation of Clinical and Biochemical Hyperandrogenism in Thai Women with Polycystic Ovary Syndrome

14 citations , February 2016 in “Journal of Obstetrics and Gynaecology Research”

Blood tests are needed to confirm high male hormone levels in women with PCOS, as physical signs alone are not reliable.

research Hyperandrogenism in Women: Polycystic Ovary Syndrome

3 citations , January 2012 in “Hanyang Medical Reviews”

The document concludes that more research is needed to create suitable diagnostic criteria and understand PCOS in Korean women, and genetics may allow for personalized treatment.

research Polycystic Ovary Syndrome and Acne

10 citations , January 2011 in “Skin therapy letter”

Women with PCOS often have acne because of high androgen levels, and the article reviewed how to treat this type of acne.

research Diagnosis of Hyperandrogenism: Clinical Criteria

85 citations , June 2006 in “Best Practice & Research Clinical Endocrinology & Metabolism”

The document concludes that hirsutism is the main sign for diagnosing hyperandrogenism, which requires a detailed patient history and physical exam.