Effects of the Prenatal and Postnatal Nurturing Environment on the Phenotype and Gut Microbiota of Mice with Polycystic Ovary Syndrome Induced by Prenatal Androgen Exposure: A Cross-Fostering Study

    March 2024 in “ Frontiers in Cell and Developmental Biology ”
    Akari Kusamoto, Miyuki Harada, Ayaka Minemura, Asami Matsumoto, Kentaro Oka, Motomichi Takahashi, Nanoka Sakaguchi, Jerilee Mariam Khong Azhary, Hiroshi Koike, Zixin Xu, Tsurugi Tanaka, Yoko Urata, Chisato Kunitomi, Nozomi Takahashi, Osamu Wada‐Hiraike, Yasushi Hirota, Yutaka Osuga
    TLDR Prenatal and postnatal environments both affect PCOS development and gut microbiota in mice.
    This study investigates the impact of prenatal and postnatal environments on the development of polycystic ovary syndrome (PCOS) and gut microbiota changes in mice. Using a cross-fostering model, researchers found that female offspring exposed to prenatal androgens but fostered by normal dams showed less severe PCOS-like phenotypes, particularly in metabolic aspects, compared to those not cross-fostered. The gut microbiota of these fostered offspring resembled controls before adolescence but diverged after young adulthood. The findings suggest that both prenatal androgen exposure and the postnatal environment significantly influence the development of PCOS-like traits and gut microbiota alterations, highlighting both as potential targets for PCOS prevention.
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