Pregnancy in Postpartum Estrus Induces Inflammatory Milk Production and Catagen-Specific Pup Skin Inflammation in Interleukin-10 Deficient Mice

July 2013 in “ Journal of Dermatological Science ”

Woo Sung Hwang, Hyun Il Kim, You Jeong Kim, Byeong Cheol Kang, Hak Sun Lee, Keun Hee Oh, Dong Sup Lee, Su Cheong Yeom

interleukin-10 IL-10 alopecia catagen inflammatory milk hepatocyte steatosis skin inflammation hair loss hair breaking inflammation

TLDR Pregnancy right after giving birth in mice lacking IL-10 causes milk that leads to liver issues and hair loss in their babies.

The study from December 2013 focused on the role of interleukin-10 (IL-10) in the development of pup alopecia due to inflammatory milk produced by IL-10 deficient mice (B6.IL-10-/-) during pregnancy in postpartum estrus (PPE). The researchers conducted 13 breeding cases and various tests, including histological examination and fostering tests, to determine the effects of the inflammatory milk. They found that the milk produced by B6.IL-10-/- dams during PPE led to hepatocyte steatosis and catagen stage specific hair breaking and alopecia in pups. The study concluded that IL-10 is crucial for regulating maternal stress and preventing the production of inflammatory milk, which in turn influences the severity of skin inflammation and alopecia in pups. The number of mice used in the study was not specified.

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