Pregnancy in Postpartum Estrus Induces Inflammatory Milk Production and Catagen-Specific Pup Skin Inflammation in Interleukin-10 Deficient Mice

    Woo Sung Hwang, Hyun Il Kim, You Jeong Kim … Su Cheong Yeom
    Studysummary This study found that interleukin-10 deficiency in B6 mice led to inflammatory milk production due to maternal stress, causing alopecia and hepatocyte steatosis in pups.
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    Research cited in this study 7

    1. Update on the Genetics of Androgenetic Alopecia, Female Pattern Hair Loss, and Alopecia Areata: Implications for Molecular Diagnostic Testing Seminars in Cutaneous Medicine and Surgery · 2012
    2. Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: An Update Journal of Dermatological Science · 2012
    3. Maternal Western Diet Causes Inflammatory Milk and TLR2/4-Dependent Neonatal Toxicity Genes & Development · 2012
    4. Primary Follicular Dystrophy With Scarring Dermatitis in C57BL/6 Mouse Substrains Resembles Central Centrifugal Cicatricial Alopecia in Humans Veterinary pathology · 2010
    5. Alopecia in IL-10-Deficient Mouse Pups Is c-Kit-Dependent and Can Be Triggered by Iron Deficiency Experimental Dermatology · 2010
    6. Maternal PPARγ Protects Nursing Neonates by Suppressing the Production of Inflammatory Milk Genes & Development · 2007
    7. Expression of Cyclooxygenase Isozymes During Morphogenesis and Cycling of Pelage Hair Follicles in Mouse Skin: Precocious Onset of the First Catagen Phase and Alopecia Upon Cyclooxygenase-2 Overexpression Journal of Investigative Dermatology · 2003