An Efficient, Non-Invasive Approach for In Vivo Sampling of Hair Follicles: Design and Applications in Monitoring DNA Damage and Aging

December 2021 in “ Aging ”

Natálie Kudlová, Hanuš Slavík, Pavlína Dušková, Tomáš Fürst, Josef Srovnal, Jiří Bártek, Martin Mistrík, Marián Hajdúch

hair follicles DNA damage aging epithelial cells genotyping quantitative PCR immunofluorescence biopsies 3 Rs principle cancer mouse hair follicular cells human hair follicles irradiated ex vivo skin cells qPCR mouse hair cells human hair cells

Studysummary This study demonstrated that a new non-invasive method for collecting and analyzing mouse hair follicles could replace traditional biopsy methods, providing advantages for translational research and routine applications.

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research A Simple Method Using Ex Vivo Culture of Hair Follicle Tissue to Investigate Intrinsic Circadian Characteristics in Humans

12 citations , July 2017 in “Scientific reports”

In this study, researchers developed a simple, non-invasive method to monitor circadian gene expression using whole hair root cultures, finding that elderly dementia patients' peripheral clocks still oscillate similarly to younger, healthier individuals, which suggests cellular senescence minimally affects some aspects of circadian rhythms.

research Keratinocyte Stem Cells but Not Melanocyte Stem Cells Are the Primary Target for Radiation-Induced Hair Graying

30 citations , April 2013 in “Journal of Investigative Dermatology”

This study found that ionizing radiation primarily affects keratinocyte stem cells in the hair follicle, suggesting they play a central role in radiation-induced hair graying, rather than melanocyte stem cells.

research Investigation of a Non-Invasive Method of Assessing the Equine Circadian Clock Using Hair Follicle Cells

15 citations , October 2012 in “Journal of circadian rhythms”

This study found that extracting RNA from equine hair follicles can effectively identify 24-hour oscillations of specific circadian clock genes, offering a valuable non-invasive method to evaluate the equine circadian clock.

research The Biology of Hair Follicles

1113 citations , August 1999 in “The New England Journal of Medicine”

This article discusses the biologic and psychosocial significance of hair, the current limitations in hair growth drugs, and anticipates future therapies based on advancing hair follicle research.