Gentamicin-Loaded Exosomes From Immunepotent CRP Enhance Healing Of Infected Diabetic Wounds In Mice

    November 2025 in “ OPAL (Open@LaTrobe) (La Trobe University) ”
    Paola Leonor García Coronado (18582106), Brandon Alberto Garza Martínez (22695917), Kenia Arisbe Moreno Amador (22695920), David Reding Hernández (22695923), Diana G. Zárate Triviño (22695926), Diana Elia Caballero Hernández (22695929), Pablo Zapata Benavides (18582121), Gabriel Luna Barcenas (22695932), Cristina Rodríguez‐Padilla (22695935), Moisés Armides Franco Molina (18582109)
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    Studysummary This study found that gentamicin-loaded exosomes derived from bovine leukocyte spleen extract enhanced antimicrobial activity and promoted tissue regeneration in infected diabetic mouse wounds, suggesting a potential innovative therapeutic strategy for diabetic foot ulcers by combining infection control with pro-regenerative and immunomodulatory effects.
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    The study investigates the use of gentamicin-loaded exosomes derived from IMMUNEPOTENT CRP to treat infected diabetic wounds in mice. The results show that these exosomes significantly enhance collagen deposition, blood vessel formation, and hair follicle regeneration, while also modulating the inflammatory response by reducing pro-inflammatory cytokines and increasing anti-inflammatory IL-10. This suggests that gentamicin-loaded exosomes could be an effective and less invasive treatment for diabetic foot ulcers, offering both infection control and regenerative benefits.
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